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Researchers have discovered that diabetes drug may reverse heart failure…

Researchers at the Icahn college of medicine at Mount Sinai have demonstrated that the recently developed medication empagliflozin will treat and reverse the progression of heart disease in non-diabetic animal models. Their study shows that this drug can make the heart produce additional energy and function more efficiently.

The results were revealed in the April 23 issue of the Journal of the American school of cardiology.

This drug may well be a promising treatment for heart disease in both non-diabetic and diabetic patients,” said lead author Juan Badimon, MD, professor of cardiology and Director of the Atherothrombosis Research Unit at the Cardiovascular Institute at the Icahn college of medicine at Mount Sinai. “Our analysis can lead to a possible application in humans, save lives, and improve quality of life.

Empagliflozin was approved by the U.S. Food and Drug Administration in 2014. It limits renal sugar reabsorption and is the first drug in the history of type 2 diabetes tested to prolong survival. whereas diabetes patients are generally at higher risk of heart failure, past studies have recommended that those that take empagliflozin do not commonly develop heart failure.

Those observations led a team of researchers to question if the drug contains a mechanism, independent of anti-diabetic activity that’s linked to heart failure prevention, and whether or not it may have an identical impact on non-diabetics

Investigators from the Atherothrombosis research Unit tested the hypothesis by inducing heart failure in fourteen non-diabetic pigs. for two months, they treated half the animals with empagliflozin and therefore the other group with a place.

The team evaluated the pigs with cardiac magnetic resonance, 3D-echocardiography, and invasive catheterization at three completely different points in the study (before inducing, one day after inducing, and at the two-month mark).

At two months, all animals in the group treated with empagliflozin experienced improved heart function. Specifically, those pigs had less water accumulation in the lungs (less pulmonary congestion, that is liable for inflicting shortness of breath) and lower levels of biomarkers of heart failure. Importantly, the left ventricles had stronger contractions (enhanced systolic function), got smaller (less dilated), and were less thick (less hypertrophy), and the heart was a normal shape (less architectural remodelling)

The researchers found that the drug addressed heart failure by improving cardiac metabolism. The hearts of pigs on the medication were consuming a lot of fatty acids and ketone bodies (three connected compounds–acetone, acetoacetic acid, and beta-hydroxybutyric acid–produced throughout the metabolism of fats) and fewer glucose, as contrasted with heart failure patients (diabetic and non-diabetic), whose hearts consume a lot of glucose and nearly no fatty acids and produces less energy.

This boost in metabolism helped the hearts turn out additional energy and function more powerfully and efficiently.

This study confirmed our hypothesis that empagliflozin is an incredibly effective treatment for heart failure and not solely an antidiabetic drug. Moreover, this study demonstrated that empagliflozin is helpful for heart failure severally of a patient’s diabetic status. importantly, empagliflozin switches cardiac metabolism toward carboxylic acid and ketone body consumption, therefore allowing the production of more energy in the heart,” explained co-lead author Glen Gebhard Santos-Gallego, MD, a postdoctoral fellow at the Icahn college of medicine at Mount Sinai.

Empagliflozin is also a potentially effective treatment for heart failure patients. this is very vital because heart failure is a disease with mortality on top of 50 p. cat five years. This study offers a brand new therapeutic strategy in heart failure, something badly required as long as there hasn’t been a new effective medicine for heart failure since the Nineties.

The authors are presently learning whether or not empagliflozin is a good heart failure treatment in non-diabetic human patients in the EMPATROPISM test.

Mount Sinai Heart is one in all the nation’s top ten hospitals in Cardiology/Heart Surger

Mount Sinai’s vision is to provide the safest care, the best quality, the best satisfaction, the most effective access and the best value of any health system in the nation.

The Health System includes more or less seven,480 primary and speciality care physicians; eleven joint-venture ambulant surgery centres; over 410 ambulatory practices throughout the five boroughs of recent York City, Westchester, Long Island, and Florida; and thirty-one attached community health centres.



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